CONSIDERATIONS TO KNOW ABOUT LSD VIAL

During the LSD-certain crystal construction, the side chain of the lid residue L209EL2 types considerable hydrophobic contacts with the two LSD and bordering residues in TMs III, IV, and V (Figure 4C). If the lid moved apart to show the binding pocket in simulation, a number of of such contacts broke. We thus hypothesized that L209EL2 functions as